Current Therapeutic Research
Volume 72, Issue 6 , Pages 243-249, December 2011

Hemodynamic Effects of Epinephrine in Healthy and Hemorrhagic Shock Rats

  • Jing Wu, MD

      Affiliations

    • Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China
    • ,
  • Dong-sheng Zhang, MD

      Affiliations

    • Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou, People's Republic of China
    • ,
  • Mu-huo Ji, MD

      Affiliations

    • Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China
    • ,
  • Zhuan Zhang, MD

      Affiliations

    • Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou, People's Republic of China
    • Corresponding Author InformationAddress correspondence to: Zhuan Zhang, MD, Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou 225001, Jiangsu Province, People's Republic of China
    • ,
  • Jian-jun Yang, MD, PhD

      Affiliations

    • Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China

Accepted 25 October 2011.

Abstract 

Objective

The aim of this study was to investigate the hemodynamic effects of epinephrine intravenous injection in healthy and hemorrhagic shock rats.

Methods

Forty Sprague-Dawley male rats weighing 250 to 300 g were randomly assigned to 4 groups: group NE, healthy rats receiving epinephrine 2 μg/kg; group NS, healthy rats receiving normal saline; group SE, hemorrhagic shock rats receiving epinephrine 2 μg/kg; and group SS, hemorrhagic shock rats receiving normal saline. Mean arterial blood pressure (MAP) and heart rate (HR) were recorded at the following time points: 0 seconds (baseline), 5 seconds, 15 seconds, 30 seconds, 1 minute, 2 minutes, 4 minutes, 6 minutes, 8 minutes, and 10 minutes (T0–9) after intravenous injection.

Results

There were no significant differences in MAP and HR at baseline between groups NS and NE or between groups SS and SE. Compared with the figures for baseline, MAP had no significant change at all time points in groups NS and SS. MAP increased at T1–9 in group SE (P < 0.01). MAP increased at T1–3 and decreased at T5–6 in group NE (P < 0.01). There was no significant change in HR in all groups after epinephrine or normal saline injection.

Conclusion

Epinephrine 2 μg/kg intravenous injection elicited biphasic changes in blood pressure, which included an initial increase and a subsequent decrease in healthy rats and induced a remarkable increase in blood pressure in hemorrhagic shock rats.

Key Words:  epinephrine , health , hemodynamics , hemorrhagic shock , rats

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PII: S0011-393X(11)00148-2

doi:10.1016/j.curtheres.2011.10.001

Current Therapeutic Research
Volume 72, Issue 6 , Pages 243-249, December 2011

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