Current Therapeutic Research
Volume 72, Issue 6 , Pages 243-249 , December 2011

Hemodynamic Effects of Epinephrine in Healthy and Hemorrhagic Shock Rats

  • Jing Wu, MD

      Affiliations

    • Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China
    • ,
  • Dong-sheng Zhang, MD

      Affiliations

    • Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou, People's Republic of China
    • ,
  • Mu-huo Ji, MD

      Affiliations

    • Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China
    • ,
  • Zhuan Zhang, MD

      Affiliations

    • Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou, People's Republic of China
    • Corresponding Author InformationAddress correspondence to: Zhuan Zhang, MD, Department of Anesthesiology, Yangzhou No.1 People's Hospital, Yangzhou 225001, Jiangsu Province, People's Republic of China
    • ,
  • Jian-jun Yang, MD, PhD

      Affiliations

    • Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China

,Accepted 25 October 2011.

References 

  1. Moss J , Glick D . The autonomic nervous system . In:  Miller RD editors. Miller's Anesthesia . 6th ed.. Philadelphia, Pa: Churchill Livingstone, Inc; 2005;p. 648
  2. Yang JJ , Zheng J , Liu HJ , et al.  Epinephrine infiltration on nasal field causes significant hemodynamic changes: hypotension episode monitored by impedance-cardiography under general anesthesia . J Pharm Pharm Sci . 2006;9:190–197
  3. Yang JJ , Cheng HL , Shang RJ , et al.  Hemodynamic changes due to infiltration of the scalp with epinephrine-containing lidocaine solution: a hypotensive episode before craniotomy . J Neurosurg Anesthesiol . 2007;19:31–37
  4. Murthy HS , Rao GS . Cardiovascular responses to scalp infiltration with different concentrations of epinephrine with or without lidocaine during craniotomy . Anesth Analg . 2001;92:1516–1519
  5. Zhang Z , Duan ML , Yang JJ , et al.  Hemodynamic effects of an intravenous bolus of epinephrine in healthy rats: a randomized, open-label, controlled pilot study . Curr Ther Res Clin E . 2008;69:440–448
  6. Linton NW , Linton RA . Haemodynamic response to a small intravenous bolus injection of epinephrine in cardiac surgical patients . Eur J Anaesthesiol . 2003;20:298–304
  7. Zakariael R , Tsakadze NL , Garrison RN . Hypertonic saline resuscitation improves intestinal microcirculation in a rat model of hemorrhagic shock . Surgery . 2006;140:579–587
  8. Kailash P , Lee P . Role of oxyradicals in the pathophysiology of hemorrhagic shock . Intl J Angiol . 2002;11:113–128
  9. Mink SN , Bands C , Becker A , et al.  Effect of bolus epinephrine on systemic hemodynamics in canine anaphylactic shock . Cardiovasc Res . 1998;40:546–556
  10. Mink SN , Simons FE , Simons KJ , et al.  Constant infusion of epinephrine, but not bolus treatment, improves haemodynamic recovery in anaphylactic shock in dogs . Clin Exp Allergy . 2004;34:1776–1783

PII: S0011-393X(11)00148-2

doi: 10.1016/j.curtheres.2011.10.001

Current Therapeutic Research
Volume 72, Issue 6 , Pages 243-249 , December 2011

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